NMARQ Ablation for Atrial Fibrillation: Results from a Multicenter Study. (16th June 2015)

• Record Type: Journal Article
• Authors: MAHIDA, SAAGAR; HOOKS, DARREN A.; NENTWICH, KARIN; NG, G. ANDRE; GRIMALDI, MASSIMO; SHIN, DONG‐IN; DERVAL, NICOLAS; SACHER, FREDERIC; BERTE, BENJAMIN; YAMASHITA, SEIGO; DENIS, ARNAUD; HOCINI, MÉLÈZE; DENEKE, THOMAS; HAISSAGUERRE, MICHEL; JAIS, PIERRE
• Is Part Of: Journal of cardiovascular electrophysiology. Volume 26:Number 7(2015:Jul.)
• Page Start: 724
• Page End: 729
• Publication Date: 2015-06-16
• Subjects: Blood vessels -- Physiology -- Periodicals; Electrophysiology -- Periodicals; Heart -- Physiology -- Periodicals; 612.1
• DOI: 10.1111/jce.12698
• Languages: English
• ISSNs: 1045-3873

Abstract

<abstract abstract-type="main"> <title>nMARQ AF Ablation</title> <sec id="jce12698-sec-0010" sec-type="section"> <title>Background</title> <p>nMARQ is a multipolar catheter designed to simultaneously ablate at multiple sites around the pulmonary vein (PV) circumference with a single radiofrequency application. We sought to define the safety and efficacy of atrial fibrillation (AF) ablation with the nMARQ catheter.</p> </sec> <sec id="jce12698-sec-0020" sec-type="section"> <title>Methods</title> <p>In a multicenter study, patients with drug‐refractory AF were included. Procedural outcomes were documented at 1 year.</p> </sec> <sec id="jce12698-sec-0030" sec-type="section"> <title>Results</title> <p>374 patients underwent PV isolation using nMARQ (age 60 ± 10 years, 264 male), of whom 263 patients had paroxysmal AF (PAF), while 111 patients had persistent AF. A total of 1, 468 of 1, 474 veins (99.6%) were isolated with the nMARQ catheter alone. Thirty‐five (13%) PAF patients and 30 (27%) persistent AF patients underwent additional ablation at non‐PV sites (2.4 ± 1.4 non‐PV sites). Procedure time for PV isolation only was 1.9 ± 0.7 hours (fluoroscopy 24 ± 14 minutes). Procedure time for PV isolation and non‐PV ablation was 2.4 ± 1.0 hours (fluoroscopy 30 ± 23 minutes). Major adverse events occurred in two patients (0.5%); one esophago‐pericardial fistula and a second, mortality due to sepsis of unknown cause. One‐year follow‐up data were available in 65 (25%) PAF and 20 (18%) persistent AF patients. Forty‐two (65%) PAF and 13 (65%) persistent AF patients were free of arrhythmia at 1 year. In patients undergoing repeat procedures (n = 17) the most frequent points of PV reconnection were: anterior RSPV, inferior RIPV, and superior LSPV.</p> </sec> <sec id="jce12698-sec-0040" sec-type="section"> <title>Conclusions</title> <p>AF ablation with nMARQ is associated with short procedure times and high acute success rates. Further research is necessary to more clearly define long‐term outcome.</p> </sec> </abstract>