A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells. (15th December 2014)

• Record Type: Journal Article
• Authors: Qiu, Qianqian; Deng, Xin; Jiao, Lei; Zhao, Tianxiao; Meng, Fanfei; Huang, Wenlong; Qian, Hai
• Is Part Of: Chemical biology & drug design. Volume 86:Number 2(2015:Aug.)
• Page Start: 173
• Page End: 179
• Publication Date: 2014-12-15
• Subjects: Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.12483
• Languages: English
• ISSNs: 1747-0277

Abstract

<abstract abstract-type="main" id="cbdd12483-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A novel coumarin‐based fluorescence probe has been constructed for the selective and sensitive detection of hydrogen sulfide (H₂S). This probe displays high sensitivity and linearity to H₂S in degassed PBS buffers and fetal bovine serum. It reacts with H₂S with high selectivity over Cys, GSH, and other anions. Meanwhile, successful detection of H₂S in living cells was also demonstrated.</p> </abstract>