Low neural exosomal levels of cellular survival factors in Alzheimer's disease. Issue 7 (13th May 2015)

• Record Type: Journal Article
• Authors: Goetzl, Edward J.; Boxer, Adam; Schwartz, Janice B.; Abner, Erin L.; Petersen, Ronald C.; Miller, Bruce L.; Carlson, Olga D.; Mustapic, Maja; Kapogiannis, Dimitrios
• Is Part Of: Annals of clinical and translational neurology. Volume 2:Issue 7(2015:Jul.)
• Page Start: 769
• Page End: 773
• Publication Date: 2015-05-13
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.211
• Languages: English
• ISSNs: 2328-9503

Abstract

<abstract abstract-type="main" id="acn3211-abs-0001"> <title>Abstract</title> <p>Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural‐derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low‐density lipoprotein receptor‐related protein 6, heat‐shock factor‐1, and repressor element 1‐silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (<italic>P</italic> &lt; 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1‐silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.</p> </abstract>