Influence of surgical margins on local recurrence in T1/T2 oral squamous cell carcinoma. Issue 8 (4th August 2014)

• Record Type: Journal Article
• Authors: Barry, Conor P.; Ahmed, Ferhan; Rogers, Simon N.; Lowe, Derek; Bekiroglu, Fazilet; Brown, James S.; Shaw, Richard J.
• Is Part Of: Head & neck. Volume 37:Issue 8(2015:Aug.)
• Page Start: 1176
• Page End: 1180
• Publication Date: 2014-08-04
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23729
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23729-sec-0001" sec-type="section"> <title>Background</title> <p>The purpose of this study was to explore the significance of resection margin status on local recurrence and survival for early (T1/T2) oral cancer and to determine if the significance of the resection margin varies with the biological aggression of the tumor as determined by pN status.</p> </sec> <sec id="hed23729-sec-0002" sec-type="section"> <title>Methods</title> <p>The influence of resection margin size and local recurrence for 295 patients with pT1/T2 oral cavity squamous cell carcinomas (SCCs) treated by primary surgery, including neck dissection, between 1998 and 2010 was analyzed.</p> </sec> <sec id="hed23729-sec-0003" sec-type="section"> <title>Results</title> <p>Overall, there was a trend toward increased local recurrence with close or involved margins. When stratified according to nodal status, there was no relationship between margin size and local recurrence for the pN0 group.</p> </sec> <sec id="hed23729-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The size of the resection margin does not seem to influence local control in stage I/II oral cancer. With future advances in preoperative neck staging, this data may help plan personalized therapy in head and neck cancer. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic><bold>37:</bold> 1176–1180, 2015</p> </sec> </abstract>