Pleural‐based neuroblastoma‐like schwannoma: A case report with cytologic findings and review of literature. Issue 8 (4th May 2015)

• Record Type: Journal Article
• Authors: Adams, Kristen; Liu, Xuehui Susan; Akhtar, Israh; Flowers, Rhyne; Baliga, Mithra
• Is Part Of: Diagnostic cytopathology. Volume 43:Issue 8(2015:Aug.)
• Page Start: 650
• Page End: 653
• Publication Date: 2015-05-04
• Subjects: Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.23293
• Languages: English
• ISSNs: 8755-1039

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We report a rare case of a 45‐year‐old African American woman with Neuroblastoma‐like Schwannoma (Neurilemmoma) occurring in the posterior mediastinum as a pleural‐based mass noted on computed tomography (CT) scan.</p> <p>A CT‐guided core biopsy of the mass was performed and core biopsy imprints were prepared during the procedure. A Diff‐Quik stain was performed for on‐site evaluation of specimen adequacy. The hematoxylin and eosin (H&amp;E) staining was evaluated subsequently. Immunohistochemistry panels were applied to the same specimen.</p> <p>The cytologic findings of the core biopsy imprints showed hypercellular smears with a predominance of small cells with atypical features including hyperchromatic, round nuclei and occasional nucleoli. Neurocytic rosettes were particularly appreciated on H&amp;E stain. The immunohistochemical results exhibited strong and diffuse immunoreactivity for S‐100 and vimentin.</p> <p>This case enriches the cytopathology literature by providing awareness of this tumor presenting as a posterior mediastinal mass. Diagn. Cytopathol. 2015;43:650–653. © 2015 Wiley Periodicals, Inc.</p> </abstract>