MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma. Issue 1 (28th September 2015)

• Record Type: Journal Article
• Authors: Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank
• Is Part Of: Cancer letters. Volume 366:Issue 1(2015)
• Page Start: 123
• Page End: 132
• Publication Date: 2015-09-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.06.015
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">An unbiased LIN28B 3′UTR-miRNA library screen identifies 28 miRNAs targeting LIN28B.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">miR-26a-5p and miR-26b-5p are top candidate LIN28B-targeting miRNAs in neuroblastoma.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Overexpression of miR-26a-5p or miR-26b-5p reduces LIN28B expression.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">MYCN does not inhibit transcription of mir-26, yet mature miR-26 miRNAs are downregulated in MYCN-driven neuroblastoma.</p> </list-item> <list-item id="u0035"> <label></label> <p id="p0035">MYCN induces LIN28B expression in neuroblastoma cells.</p> </list-item> </list> </p> </sec> </abstract>