Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma. Issue 1 (28th September 2015)

• Record Type: Journal Article
• Authors: Geng, Ya-di; Zhang, Chao; Shi, Ya-min; Xia, Yuan-zheng; Guo, Chao; Yang, Lei; Kong, Ling-yi
• Is Part Of: Cancer letters. Volume 366:Issue 1(2015)
• Page Start: 19
• Page End: 31
• Publication Date: 2015-09-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.05.032
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">IS induces apoptosis through mitochondrial and lysosomal membrane permeabilization in HepG2 cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Impairs autophagosome degradation is involved in IS-induced autophagosome accumulation in HepG2 cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">IS-induced autophagosome accumulation plays a pro-survival role through engulfing dysfunctional lysosomes and mitochondria.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">IS exhibits anti-tumor effect in mice transplanted with H22 liver carcinomas with the same mechanism as <italic>in vitro</italic>.</p> </list-item> </list> </p> </sec> </abstract>