Antibacterial Δ1‐3‐Ketosteroids from the South China Sea Gorgonian Coral Subergorgia rubra. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Sun, Xue‐Ping; Cao, Fei; Shao, Chang‐Lun; Wang, Mei; Zhang, Xiu‐Li; Wang, Chang‐Yun
• Is Part Of: Chemistry & biodiversity. Volume 12:Issue 7(2015:Jul.)
• Page Start: 1068
• Page End: 1074
• Publication Date: 2015-07
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201400217
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Three new Δ¹‐3‐ketosteroids characterized with a 9‐OH, subergosterones A–C (<bold>1</bold>–<bold>3</bold>), together with five known analogs <bold>4</bold>–<bold>8</bold>, were obtained from the gorgonian coral <italic>Subergorgia rubra</italic> collected from the South China Sea. The structures of <bold>1</bold>–<bold>3</bold>, including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds <bold>2</bold> and <bold>3</bold> exhibited inhibitory antibacterial activities against <italic>Bacillus cereus</italic> with <italic>MIC</italic> values of 1.56 μ<sc>M</sc>.</p> </abstract>