A case of hypertrophic cranial pachymeningitis associated with invasive Aspergillus mastoiditis. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Okada, Masahiro; Hato, Naohito; Okada, Yoko; Sato, Eriko; Yamada, Hiroyuki; Hakuba, Nobuhiro; Gyo, Kiyofumi
• Is Part Of: Auris nasus larynx. Volume 42:Issue 6(2015)
• Page Start: 488
• Page End: 491
• Publication Date: 2015-12
• Subjects: Otolaryngology -- Periodicals; Electronic journals; 616
• DOI: 10.1016/j.anl.2015.04.009
• Languages: English
• ISSNs: 0385-8146

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <p id="spar0005">We report a rare case of hypertrophic cranial pachymeningitis (HCP) associated with invasive <italic>Aspergillus</italic> mastoiditis. A 63-year-old man with diabetes mellitus underwent mastoidectomy because of chronic discharge from his left ear. The mastoidectomy was unsuccessful in resolving purulent otorrhea; moreover, 7 months later, the patient developed left abducens nerve palsy. Magnetic resonance imaging revealed HCP at the left middle cranial fossa. Although the pathogen could not be identified, an <italic>Aspergillus</italic> infection was considered based on elevated serum β-<sc>d</sc>-glucan and a positive <italic>Aspergillus</italic> antigen test result. Voriconazole treatment resolved diplopia and left otorrhea and dramatically improved HCP.</p> </sec> </abstract>