Nasal manifestations of IgG4-related disease: A report of two cases. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Ohno, Keiko; Matsuda, Yoko; Arai, Tomio; Kimura, Yurika
• Is Part Of: Auris nasus larynx. Volume 42:Issue 6(2015)
• Page Start: 483
• Page End: 487
• Publication Date: 2015-12
• Subjects: Otolaryngology -- Periodicals; Electronic journals; 616
• DOI: 10.1016/j.anl.2015.05.004
• Languages: English
• ISSNs: 0385-8146

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <p id="spar0005">IgG4-related disease (IgG4-RD) is a recently recognized clinical disease entity characterized by elevated serum IgG4, tumefaction, tissue infiltration of IgG4-positive plasma cells and fibrosis. IgG4-RD may occur, either synchronously or metachronously, in a variety of organs throughout the body. We describe herein two representative cases of the nasal manifestations of IgG4-RD, characterized by diffuse, crusty, erosive lesions on nasal mucosa. Oral steroid administration was effective in treating these nasal manifestations. We report a decrease in IgG4 positive plasma cell infiltrates in nasal mucosa biopsy specimens after steroid therapy, demonstrating that infiltration of IgG4-positive cells is reversible.</p> </sec> </abstract>