Assessment of HEMA and TEGDMA induced DNA damage by multiple genotoxicological endpoints in human lymphocytes. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Ginzkey, Christian; Zinnitsch, Sabrina; Steussloff, Gudrun; Koehler, Christian; Hackenberg, Stephan; Hagen, Rudolf; Kleinsasser, Norbert H.; Froelich, Katrin
• Is Part Of: Dental materials. Volume 31:Issue 8(2015)
• Page Start: 865
• Page End: 876
• Publication Date: 2015-08
• Subjects: Dentistry -- Periodicals; Dental materials -- Periodicals; 617.695
• DOI: 10.1016/j.dental.2015.04.009
• Languages: English
• ISSNs: 0109-5641

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Human lymphocytes were exposed to HEMA and TEGDMA for 24 h.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Cytotoxic effects were measured only in TEGDMA (100 μM) treated cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Genotoxic effects were detected in the comet assay at the highest concentrations.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">No increase in the micronucleus frequency or an arrest of the cell cycle was shown.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Chromosome aberrations and SCEs were recorded at lowest concentrations tested.</p> </list-item> </list> </p> </sec> </abstract>