Exploring effects of a natural combination medicine on exercise‐induced inflammatory immune response: A double‐blind RCT. Issue 4 (12th June 2014)

• Record Type: Journal Article
• Authors: Pilat, C.; Frech, T.; Wagner, A.; Krüger, K.; Hillebrecht, A.; Pons‐Kühnemann, J.; Scheibelhut, C.; Bödeker, R.‐H.; Mooren, F.‐C.
• Is Part Of: Scandinavian journal of medicine & science in sports. Volume 25:Issue 4(2015)
• Page Start: 534
• Page End: 542
• Publication Date: 2014-06-12
• Subjects: Sports medicine -- Periodicals; Sports -- Physiological aspects -- Periodicals; Sports -- Periodicals; 617.1027
• DOI: 10.1111/sms.12265
• Languages: English
• ISSNs: 0905-7188

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise‐induced immune response. In a double‐blind, randomized, controlled trial, healthy, untrained male subjects received either Tr14 (<italic>n =</italic> 40) or placebo (<italic>n =</italic> 40) for 24 h after a strenuous experimental exercise trial on a bicycle (60 min at 80%VO<sub>2</sub><sub>max</sub>). A range of antigen‐stimulated cytokines (<italic>in vitro</italic>), white blood cell count, lymphocyte activation and apoptosis markers, and indicators of muscle damage were assessed up to 24 h following exercise. The area under the curve with respect to the increase (AUC<sub>I</sub>) was compared between both groups. The Tr14 group showed a reduced exercise‐induced leukocytosis and neutrocytosis (<italic>P</italic> < 0.01 for both), a higher AUC<sub>I</sub> score of antigen‐stimulated IL‐1β and IL‐1α (absolute and per monocyte, all <italic>P</italic> < 0.05), a lower AUC<sub>I</sub> score of antigen‐stimulated GM‐CSF (<italic>P</italic> < 0.05) and by trend a lower AUC<sub>I</sub> score of antigen‐stimulated IL‐2 and IL‐4 as well as a higher AUC<sub>I</sub> score of antigen‐stimulated IL‐6 (all <italic>P</italic> < 0.1). Tr14 might promote differentiated effects on the exercise‐induced immune response by (a) decreasing the inflammatory response of the innate immune system; and (b) augmenting the pro‐inflammatory cytokine response.</p> </abstract>