Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study. (1st June 2015)

• Record Type: Journal Article
• Authors: Ponto, K. A.; Elbaz, H.; Peto, T.; Laubert‐Reh, D.; Binder, H.; Wild, P. S.; Lackner, K.; Pfeiffer, N.; Mirshahi, A.
• Is Part Of: Journal of thrombosis and haemostasis. Volume 13:Number 7(2015:Jul.)
• Page Start: 1254
• Page End: 1263
• Publication Date: 2015-06-01
• Subjects: Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.12982
• Languages: English
• ISSNs: 1538-7933

Abstract

<abstract abstract-type="main" id="jth12982-abs-0001"> <title>Summary</title> <sec id="jth12982-sec-0001" sec-type="section"> <title>Objective</title> <p>To determine the age‐ and sex‐specific prevalence and determinants of retinal vein occlusions (RVOs) in a large population‐based German cohort.</p> </sec> <sec id="jth12982-sec-0002" sec-type="section"> <title>Methods</title> <p>The investigation included 15 010 participants (aged 35–74 years) from the Gutenberg Health Study. We determined the prevalence of RVO (central retinal vein occlusion [CRVO] and branch retinal vein occlusion [BRVO]) for the local population by assessing fundus photographs of 12 954 (86.3%; 49.8% women and 50.2% men) participants. Further, we analyzed the associations of RVO with cardiovascular, anthropometric, and ophthalmic parameters.</p> </sec> <sec id="jth12982-sec-0003" sec-type="section"> <title>Results</title> <p>The weighted prevalences of RVO, CRVO, and BRVO were 0.40%, 0.08%, and 0.32%, respectively. Men were 1.7 times more frequently affected by RVO than were women. Prevalence of RVO was 0.2% in participants aged 35–44 and 45–54 years, respectively, 0.48% in those aged 55–64 years, and 0.92% in those aged 65–74 years. Of persons with RVO, 91.5% had one or more cardiovascular risk factor or disease vs. 75.9% of persons without RVO. BRVO was associated with arterial hypertension (odds ratio 2.69, 95% confidence interval 1.27–5.70) and atrial fibrillation (3.37, 1.24–9.12) and CRVO with higher age (7.02, 1.63–30.19) and a family history of stroke (4.64, 1.18–18.25). Median visual acuity (base 10 logarithm of minimum angle of resolution) was 0.2 in persons with RVO vs. 0.05 in those without.</p> </sec> <sec id="jth12982-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The prevalence of RVO in this German population was 0.4%, and men were 1.7 times more frequently affected than women. CRVO was associated with higher age and a family history of stroke, and BRVO was associated with arterial hypertension and atrial fibrillation.</p> </sec> </abstract>