Multiple inductive effects of carbamazepine on combined therapy with paliperidone and amlodipine. (26th May 2015)

• Record Type: Journal Article
• Authors: Akamine, Y.; Uehara, H.; Miura, M.; Yasui‐Furukori, N.; Uno, T.
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 40:Number 4(2015:Aug.)
• Page Start: 480
• Page End: 482
• Publication Date: 2015-05-26
• Subjects: Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.12286
• Languages: English
• ISSNs: 0269-4727

Abstract

<abstract abstract-type="main" id="jcpt12286-abs-0001"> <title>Summary</title> <sec id="jcpt12286-sec-0001" sec-type="section"> <title>What is known and objective</title> <p>Carbamazepine is a potent inducer of cytochrome P450 3A and P‐glycoprotein. However, there are no reports of the effects of carbamazepine on more than one co‐administered drug.</p> </sec> <sec id="jcpt12286-sec-0002" sec-type="section"> <title>Case summary</title> <p>A 53‐year‐old female patient with schizophrenia and hypertension was on paliperidone 12 mg/day and amlodipine 5 mg/day. When carbamazepine was added to this prescription, the plasma concentrations of both drugs decreased dramatically in a dose‐dependent manner. Although the patient's psychotic symptoms did not change, as a result, her mean blood pressure increased to 160·1/103·6 mmHg from 138·4/91·4 mmHg at a carbamazepine dose of 600 mg/day.</p> </sec> <sec id="jcpt12286-sec-0003" sec-type="section"> <title>What is new and conclusion</title> <p>Theses cases show the effect of carbamazepine induction on two drugs simultaneously. Care is required when carbamazepine is added to drug regimens including paliperidone or amlodipine alone or together.</p> </sec> </abstract>