Β‐cyclodextrin in personal care formulations: role on the complexation of malodours causing molecules. (18th March 2015)

• Record Type: Journal Article
• Authors: Lopedota, A.; Cutrignelli, A.; Laquintana, V.; Franco, M.; Donelli, D.; Ragni, L.; Tongiani, S.; Denora, N.
• Is Part Of: International journal of cosmetic science. Volume 37:Number 4(2015:Aug.)
• Page Start: 438
• Page End: 445
• Publication Date: 2015-03-18
• Subjects: Cosmetics -- Periodicals; 668.5505
• DOI: 10.1111/ics.12215
• Languages: English
• ISSNs: 0142-5463

Abstract

<abstract abstract-type="main" xml:lang="en" id="ics12215-abs-0001"> <title>Synopsis</title> <sec id="ics12215-sec-0001" sec-type="section"> <title>Objective</title> <p>The aim of this study was to prove the capability of β‐cyclodextrin (β‐CD) to interact with some representative molecules responsible to cause body malodour, such as carboxylic acids, thiols and steroids, present in sweat and body secretions.</p> </sec> <sec id="ics12215-sec-0002" sec-type="section"> <title>Methods</title> <p>The association constants in guest‐CD were determined by ¹H‐NMR spectroscopy for thiols and steroids such as 3‐mercapto‐1‐hexanol, androstenone, androstenol and androsterone, and pH‐potentiometric titration for acetic acid, <sc>l</sc>(+) lactic acid, isobutyric acid, isovaleric acid and 3‐hydroxy‐3‐methyl‐hexanoic acid.</p> </sec> <sec id="ics12215-sec-0003" sec-type="section"> <title>Results</title> <p>All considered systems are able to interact with relatively weak association constants with β‐cyclodextrin, in a 1 : 1 host–guest ratio.</p> </sec> <sec id="ics12215-sec-0004" sec-type="section"> <title>Conclusion</title> <p>From these findings, it is possible to conclude that β‐CD is capable to interact with different components present in the sweat and body secretion, forming inclusion complexes. For this reason, β‐CD could be a component of body care formulations, such as deodorants.</p> </sec> </abstract>