Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction. (25th July 2014)

• Record Type: Journal Article
• Authors: Abdel Aziz, M. T.; Rezq, A. M.; Atta, H. M.; Fouad, H.; Zaahkouk, A. M.; Ahmed, H. H.; Sabry, D.; Yehia, H. M.
• Is Part Of: Andrologia. Volume 47:Number 6(2015)
• Page Start: 616
• Page End: 625
• Publication Date: 2014-07-25
• Subjects: Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12309
• Languages: English
• ISSNs: 0303-4569

Abstract

<abstract abstract-type="main" id="and12309-abs-0001"> <title>Summary</title> <p>The efficacy of a novel curcumin derivative (NCD) versus tadalafil in erectile signalling was assessed. Ten control male rats and 50 diabetic male rats were used and divided into the following: diabetic (DM), curcumin (CURC), NCD, tadalafil and NCD combined with tadalafil rat groups. Cavernous tissue gene expression of heme oxygenase‐1 (<italic>HO‐1</italic>), <italic>Nrf2</italic>, <italic> NF</italic>‐<italic>B</italic> and <italic>p38</italic>, enzyme activities of heme oxygenase (HO) and nitric oxide synthase (NOS), cGMP and intracavernosal pressure (ICP)/mean arterial pressure (MAP) were assessed. Results showed that 12 weeks after induction of diabetes, erectile dysfunction (ED) was confirmed by the significant decrease in ICP/MAP, a significant decrease in cGMP, NOS, HO enzyme activities, a significant decrease in <italic>HO‐1</italic> gene and a significant increase in <italic>NF‐Ҡβ, p38</italic> genes. Administration of all therapeutic interventions led to a significant increase in ICP/MAP, cGMP levels, a significant increase in HO‐1 and NOS enzymes, a significant increase in <italic>HO‐1</italic>, and <italic>Nrf2</italic> gene expression, and a significant decrease in <italic>NF‐Ҡβ</italic>, <italic> p38</italic> gene expression. NCD or its combination with tadalafil showed significant superiority and more prolonged duration of action. In conclusion, a tendency was observed that CURC and NCD have high efficacy and more prolonged duration of action in enhancing erectile function.</p> </abstract>