ASSOCIATION BETWEEN NEEDLE SIZE, POSTINJECTION REFLUX, AND INTRAOCULAR PRESSURE SPIKES AFTER INTRAVITREAL INJECTIONS. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Pang, Claudine E.; Mrejen, Sarah; Hoang, Quan V.; Sorenson, John A.; Freund, K. Bailey
• Is Part Of: Retina. Volume 35:Issue 7(2015:Jul.)
• Publication Date: 2015-07
• Subjects: Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000476
• Languages: English
• ISSNs: 0275-004X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Purpose:</title> <p>To compare the effect of 30-gauge versus 32-gauge needle size on postinjection reflux and immediate postinjection intraocular pressure (IOP<sub>immed_post</sub>) spikes in eyes injected with anti-vascular endothelial growth factor agents.</p> </sec> <sec> <title>Methods:</title> <p>This was a prospective interventional case series of 65 eyes of 54 consecutive patients in a clinical practice setting who received intravitreal anti-vascular endothelial growth factor therapy. All eyes had preinjection IOP, IOP<sub>immed_post</sub>, postinjection reflux, and axial lengths recorded.</p> </sec> <sec> <title>Results:</title> <p>There was a higher incidence of postinjection reflux in eyes injected with 30-gauge (53%) compared with those injected with 32-gauge (13%, <italic>P</italic> = 0.0007). Among 34 eyes injected with 30-gauge, 16 eyes without appreciable postinjection reflux had mean IOP<sub>immed_post</sub> of 44.3 ± 7.48 mmHg and mean IOP<sub>immed_post</sub> elevation of 29.6 ± 2.10 mmHg, which was significantly higher than the 18 eyes with reflux (mean IOP<sub>immed_post</sub> of 18.8 ± 7.15 mmHg and mean IOP<sub>immed_post</sub> elevation of 4.5 ± 1.74 mmHg, <italic>P</italic> < 0.0001). Among 31 eyes injected with 32-gauge, 27 eyes without appreciable postinjection reflux had mean IOP<sub>immed_post</sub> of 44.4 ± 10.82 mmHg and mean IOP<sub>immed_post</sub> elevation of 29.5 ± 1.99 mmHg, which was significantly higher than the 4 eyes with reflux (mean IOP<sub>immed_post</sub> of 21.3 ± 8.54 mmHg and mean IOP<sub>immed_post</sub> elevation of 9.5 ± 4.05 mmHg, <italic>P</italic> < 0.001). The differences in reflux and IOP between the two groups were unrelated to axial lengths (<italic>P</italic> = 0.451).</p> </sec> <sec> <title>Conclusion:</title> <p>Eyes receiving injections with 32-gauge needles had a lower incidence of postinjection reflux and higher mean IOP immediately after injection.</p> </sec> </abstract>