A Meta-analysis Assessing Postsurgical Outcomes between Aseptic and Sterile AlloDerm Regenerative Tissue Matrix. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Macarios, David; Griffin, Leah; Chatterjee, Abhishek; Lee, Lauren J.; Milburn, Cheryl; Nahabedian, Maurice Y.
• Is Part Of: Plastic and reconstructive surgery. Volume 3:Issue 6(2015:Jun.)
• Publication Date: 2015-06
• Subjects: Surgery, Plastic -- Periodicals; Surgery, Plastic -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; 617.95205
• DOI: 10.1097/GOX.0000000000000387
• Languages: English
• ISSNs: 2169-7574

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background:</title> <p>AlloDerm, a human acellular dermal matrix, is available in a ready-to-use (RTU) or freeze-dried (FD) form. A limited number of studies have compared complication rates between RTU and FD in implant-based breast reconstruction. The objective of this report was to conduct a meta-analysis of previously reported complication rates between RTU and FD.</p> </sec> <sec> <title>Methods:</title> <p>A systematic literature review was conducted from 2010 to 2014 and supplemented by hand searches. Included studies compared both RTU and FD. Odds ratios and relative risks (RRs) with 95% confidence interval (CI), taking into account study heterogeneity, were calculated. Studies reporting patient-level results as opposed to breast-level results were excluded from the primary analysis but included in subsequent sensitivity analyses. Variable follow-up time within and between studies was also considered in a sensitivity analysis.</p> </sec> <sec> <title>Results:</title> <p>Of the 275 identified studies, 115 studies were eligible for detailed review. Only 5 studies compared RTU with FD, and of these, 2 studies had breast-level data and 1 study had patient-level data appropriate for meta-analysis. The 2 studies included in the primary meta-analysis had a pooled sample size: <italic>n</italic> = 116 RTU and <italic>n</italic> = 109 FD patients, or 205 and 186 breasts, respectively. Age and body mass index were similar between groups. Across all meta-analyses, there were no differences in complication rates between RTU and FD: cellulitis (RR = 0.863; 95% CI, 0.272–2.740), seroma (RR = 0.553; 95% CI, 0.026–11.830), and explantation (RR = 0.593; 95% CI, 0.247–1.425). Results remained nonsignificant even after adjustment for variable follow-up time.</p> </sec> <sec> <title>Conclusion:</title> <p>The results suggest that there are no differences in complication rates between RTU and FD forms.</p> </sec> </abstract>