A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. (August 2015)

• Record Type: Journal Article
• Authors: Hirano, Atsushi; Ohara, Tomoyuki; Takahashi, Atsushi; Aoki, Masayuki; Fuyuno, Yuta; Ashikawa, Kyota; Morihara, Takashi; Takeda, Masatoshi; Kamino, Kouzin; Oshima, Etsuko; Okahisa, Yuko; Shibata, Nobuto; Arai, Heii; Akatsu, Hiroyasu; Ikeda, Masashi; Iwata, Nakao; Ninomiya, Toshiharu; Monji, Akira; Kitazono, Takanari; Kiyohara, Yutaka; Kubo, Michiaki; Kanba, Shigenobu
• Is Part Of: Psychiatric genetics. Volume 25:Number 4(2015:Aug.)
• Publication Date: 2015-08
• Subjects: Mental illness -- Genetic aspects -- Periodicals; Periodicals; 616.89042
• DOI: 10.1097/YPG.0000000000000090
• Languages: English
• ISSNs: 0955-8829

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations.</p> </sec> <sec> <title>Design</title> <p>To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by <italic>APOE</italic>-ε4 status to eliminate the established effect of <italic>APOE</italic> region.</p> </sec> <sec> <title>Results</title> <p>Our data indicated that 18p11.32 (rs1992269, <italic>P</italic>=9.77×10⁻⁷), <italic>CNTNAP2</italic> (rs802571, <italic>P</italic>=1.26×10⁻⁶), and 12q24.23 (rs11613092, <italic>P</italic>=6.85×10⁻⁶) were suggestive loci for susceptibility to LOAD.</p> </sec> <sec> <title>Conclusion</title> <p>We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of <italic>CNTNAP2</italic>, was considered to be a plausible candidate locus from a functional perspective.</p> </sec> </abstract>