ENOS Genetic Polymorphisms and Cancer Risk. Issue 26 (July 2015)

• Record Type: Journal Article
• Authors: Gao, Xueren; Wang, Jie; Wang, Wenjun; Wang, Mingxi; Zhang, Jianqiong; Alkhiary., Wael
• Is Part Of: Medicine. Volume 94:Issue 26(2015)
• Publication Date: 2015-07
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000972
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>The association between endothelial nitric oxide synthase (eNOS) polymorphisms (intron 4a/b, -786T>C and 894G>T) and cancer risk remains elusive. In addition, no studies focused on their associations with the risk of breast cancer in Chinese Han population. Thus, a meta-analysis was conducted to determine the relationship between eNOS polymorphisms and cancer risk, and then a case–control study in Chinese Han population was performed to assess their associations with breast cancer susceptibility.</p> <p>Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The pooled analysis indicated that <italic>eNOS</italic> intron 4a/b and -786T>C polymorphisms were significantly associated with an increased risk of overall cancer. In subgroup analyses based on cancer type, the significant association was found between <italic>eNOS</italic> intron 4a/b polymorphism and prostate cancer risk, <italic>eNOS</italic> -786T>C polymorphism and risk of prostate, bladder and breast cancers, and <italic>eNOS</italic> 894G>T polymorphism and breast cancer risk. In subgroup analyses based on ethnicity, <italic>eNOS</italic> intron 4a/b and -786T>C polymorphisms were associated with an increased risk of cancer in Caucasians. In consistent with our meta-analysis results, a case–control study in Chinese Han population showed significant associations of <italic>eNOS</italic> -786T>C and 894G>T polymorphisms with the increased risk of breast cancer. In addition, stratified analyses based on pathological type showed that <italic>eNOS</italic> 894G>T polymorphism was only associated with the risk of infiltrative ductal carcinoma. Stratified analyses by tumor stage showed that <italic>eNOS</italic> -786T>C polymorphism was only associated with the risk of tumor stage III and IV.</p> <p>In conclusion, our meta-analysis and case–control study suggest that <italic>eNOS</italic> -786T>C and 894G>T polymorphisms are associated with the increased risk of breast cancer.</p> </sec> </abstract>