Heme Oxygenase 1 and 2 Common Genetic Variants and Risk for Essential Tremor. Issue 24 (June 2015)

• Record Type: Journal Article
• Authors: Ayuso, Pedro; Agúndez, José A.G.; Alonso-Navarro, Hortensia; Martínez, Carmen; Benito-León, Julián; Ortega-Cubero, Sara; Lorenzo-Betancor, Oswaldo; Pastor, Pau; López-Alburquerque, Tomás; García-Martín, Elena; Jiménez-Jiménez, Félix J.; Das., Undurti Narasimha
• Is Part Of: Medicine. Volume 94:Issue 24(2015)
• Publication Date: 2015-06
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000968
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Several reports suggested a role of heme oxygenase genes 1 and 2 (<italic>HMOX1</italic> and <italic>HMOX2</italic>) in modifying the risk to develop Parkinson disease (PD). Because essential tremor (ET) and PD share phenotypical and, probably, etiologic factors of the similarities, we analyzed whether such genes are related with the risk to develop ET.</p> <p>We analyzed the distribution of allelic and genotype frequencies of the <italic>HMOX1</italic> rs2071746, <italic>HMOX1</italic> rs2071747, <italic>HMOX2</italic> rs2270363, and <italic>HMOX2</italic> rs1051308 single nucleotide polymorphisms, as well as the presence of copy number variations of these genes in 202 subjects with familial ET and 747 healthy controls.</p> <p>Allelic frequencies of <italic>rs2071746T</italic> and <italic>rs1051308G</italic> were significantly lower in ET patients than in controls. None of the studied polymorphisms influenced the disease onset.</p> <p>The present study suggests a weak association between <italic>HMOX1</italic> rs2071746 and <italic>HMOX2</italic> rs1051308 polymorphisms and the risk to develop ET in the Spanish population.</p> </sec> </abstract>