Quality of Life After Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism. Issue 23 (June 2015)

• Record Type: Journal Article
• Authors: Cheng, Shih-Ping; Lee, Jie-Jen; Liu, Tsang-Pai; Yang, Po-Sheng; Liu, Sung-Chen; Hsu, Yi-Chiung; Liu, Chien-Liang; Billmann., Franck
• Is Part Of: Medicine. Volume 94:Issue 23(2015)
• Publication Date: 2015-06
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000931
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>A number of studies have investigated the effects of surgery on symptoms and quality of life in patients with hyperparathyroidism. However, the results are inconsistent. We conducted this meta-analysis to quantitatively assess changes in quality of life among patients with asymptomatic primary hyperparathyroidism.</p> <p>Different databases were searched for randomized controlled trials comparing surgery with surveillance. Quality of life was measured by the Short Form-36 general health survey. The pooled random-effects estimates of standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated.</p> <p>Three trials involving 294 participants were included. At 1 year, patients undergoing parathyroidectomy had significantly better physical role functioning (SMD, 0.31; 95% CI 0.04–0.57; <italic>P</italic> = 0.02) and emotional role functioning (SMD, 0.29; 95% CI 0.02–0.55; <italic>P</italic> = 0.03). At 2 years, the surgery group had significantly better emotional role functioning (SMD, 0.35; 95% CI 0.02–0.67; <italic>P</italic> = 0.04) than the surveillance group. Furthermore, compared with baseline, emotional role functioning improved after surgery (SMD, 0.31; 95% CI 0.02–0.60; <italic>P</italic> = 0.04), whereas emotional role functioning tended to get worse in patients assigned to medical surveillance (SMD, −0.27; 95% CI −0.55 to 0.02; <italic>P</italic> = 0.07).</p> <p>Although Short Form-36 is a generic instrument, our results suggest that parathyroidectomy may be associated with better quality of life, especially in the emotional aspects of well-being.</p> </sec> </abstract>