A Genetic Susceptibility Mechanism for Major Depression. Issue 23 (June 2015)

• Record Type: Journal Article
• Authors: Wang, Yanfang; Sun, Ning; Li, Suping; Du, Qiaorong; Xu, Yong; Liu, Zhifeng; Zhang, Kerang; Konuk., Numan
• Is Part Of: Medicine. Volume 94:Issue 23(2015)
• Publication Date: 2015-06
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000778
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Major Depression (MD) is a highly inherited psychiatric disorder. The norepinephrine transporter (<italic>NET</italic>) gene plays important role in pathophysiology of MD. This study attempted to examine the relationship between polymorphisms of <italic>NET</italic> gene and MD.</p> <p>Patients with MD and healthy controls were recruited and subgrouped. The T-182C and G1287A polymorphisms of <italic>NET</italic> gene were genotyped by direct sequencing. The genotypic and allelic frequencies were compared using the Pearson <italic>χ2</italic> analysis. The linkage disequilibrium was analyzed using the UNPHASED program.</p> <p>Significant differences in genotypic and allelic frequencies of T-182C polymorphism were observed between MD subgroups and controls. When referenced by TT genotype, the OR value increased gradient from TC to CC genotype; when referenced by T allele, the odds ratio value of C allele also increased. Compared with those having both −182 T/T and 1287 G/G genotypes, in patients with MD, early-onset MD, and MD with suicide concept group, the −182 C/C and 1287 G/A combinatorial genotype has significant risk; yet in patients with MD family history, the −182 C/C and 1287 A/A combinatorial genotype has significant risk.</p> <p>Different combinations of T-182C and the G1287A polymorphisms of <italic>NET</italic> gene might increase morbidity risk of MD subpopulations.</p> </sec> </abstract>