Intravoxel Incoherent Motion MR Imaging. Issue 25 (June 2015)

• Record Type: Journal Article
• Authors: Du, Jun; Li, Kun; Zhang, Weisheng; Wang, Shaowu; Song, Qingwei; Liu, Ailian; Miao, Yanwei; Lang, Zhijin; Zhang, Lina; Zheng, Minting; Adamek., Mariusz
• Is Part Of: Medicine. Volume 94:Issue 25(2015)
• Publication Date: 2015-06
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000001028
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>We used intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to explore the possibility of preoperative diagnosis of soft tissue tumors (STTs). This prospective study enrolled 23 patients. Conventional MRI and IVIM examinations were performed on a 3.0T MR imager. Eight (35%) hemangiomas, 11 (47%) benign soft tissue tumors excluding hemangiomas (BSTTEHs) and 4 soft tissue sarcomas (STSs) were assessed. The mean tumor size was about 1652.36 ± 233.66 mm<sup>2</sup>. Ten b values (0–800 s/mm<sup>2</sup>) were used to evaluate diffusion and perfusion characteristics of IVIM. IVIM parameters (ADC<sub>standard</sub>, ADC<sub>slow</sub>, ADC<sub>fast</sub>, and f) of STTs were measured and evaluated for differentiating hemangiomas, BSTTEHs, and STSs. ADC<sub>slow</sub> and ADC<sub>fast</sub> value were different for hemangiomas, BSTTEHs, and STSs separately (<italic>P</italic> < 0.001, <italic>P</italic> < 0.001, and <italic>P</italic> = 0.001). ADC<sub>slow</sub>, cut-off value smaller than 0.93 × 10<sup>–3</sup> mm<sup>2</sup>/s, was the best parameter to differ STSs (0.689 ± 0.173 × 10<sup>−3</sup> mm<sup>2</sup>/s) from hemangiomas (0.933 ± 0.237 × 10<sup>−3</sup> mm<sup>2</sup>/s) and BSTTEHs (1.156 ± 0.120 × 10<sup>−3</sup> mm<sup>2</sup>/s) (<italic>P</italic> = 0.001). ADC<sub>slow</sub> (0.93 × 10<sup>−3</sup> mm<sup>2</sup>/s <cut-off value <0.96 × 10<sup>−3</sup> mm<sup>2</sup>/s) was used to distinguish hemangiomas from BSTTs. There were significant difference among hemangiomas, BSTTEHs, and STSs (<italic>P</italic> <italic>=</italic> 0.014, <italic>P</italic> <italic>=</italic> 0.036, <italic>P</italic> < 0.001). The ADC<sub>standard</sub>, ADC<sub>fast</sub>, and f value were different (<italic>P</italic> <italic><</italic> 0.05) for STSs (1.009 ± 0.177 × 10<sup>−3</sup> mm<sup>2</sup>/s, 15.700 ± 1.992 × 10<sup>−3</sup> mm<sup>2</sup>/s, 0.503 ± 0.068), hemangiomas (1.505 ± 0.226 × 10<sup>−3</sup> mm<sup>2</sup>/s, 11.675 ± 0.456 × 10<sup>−3</sup> mm<sup>2</sup>/s, 0.682 ± 0.060), and BSTTEHs (1.555 ± 0.176 × 10<sup>−3</sup> mm<sup>2</sup>/s, 11.727 ± 0.686 × 10<sup>−3</sup> mm<sup>2</sup>/s, 0.675 ± 0.054). And there was no significant difference for these 3 parameters between hemangiomas and BSTTEHs (<italic>P</italic> <italic>=</italic> 0.584, 0.907, and 0.798). IVIM may be of significant value for differential diagnosing hemangiomas, BSTTEHs, and STSs.</p> </sec> </abstract>