No Development of Imipenem Resistance in Pneumonia Caused by Escherichia coli. Issue 25 (June 2015)

• Record Type: Journal Article
• Authors: Yayan, Josef; Ghebremedhin, Beniam; Rasche, Kurt; Callens., Steven
• Is Part Of: Medicine. Volume 94:Issue 25(2015)
• Publication Date: 2015-06
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000001020
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background:</title> <p>Antibiotic resistance continues to rise due to the increased number of antibiotic prescriptions and is now a major threat to public health. In particular, there is an increase in antibiotic resistance to <italic>Escherichia coli</italic> according to the latest reports.</p> </sec> <sec> <title>Trial Design:</title> <p>This article examines, retrospectively, antibiotic resistance in patients with community- and nosocomial-acquired pneumonia caused by <italic>E coli.</italic></p> </sec> <sec> <title>Methods:</title> <p>The data of all patients with community- and nosocomial-acquired pneumonia caused by <italic>E coli</italic> were collected from the hospital charts at the HELIOS Clinic, Witten/Herdecke University, Wuppertal, Germany, within the study period 2004 to 2014. An antibiogram was performed for the study patients with pneumonia caused by <italic>E coli</italic>. Antimicrobial susceptibility testing was performed for the different antibiotics that have been consistently used in the treatment of patients with pneumonia caused by <italic>E coli.</italic> All demographic, clinical, and laboratory data of all of the patients with pneumonia caused by <italic>E coli</italic> were collected from the patients' records.</p> </sec> <sec> <title>Results:</title> <p>During the study period of January 1, 2004 to August 12, 2014, 135 patients were identified with community- and nosocomial-acquired pneumonia affected by <italic>E coli</italic>. These patients had a mean age of 72.5 ± 11.6 (92 [68.1%, 95% CI 60.2%–76.0%] males and 43 [31.9%, 95% CI 24.0%–39.8%] females). <italic>E coli</italic> had a high resistance rate to ampicillin (60.7%), piperacillin (56.3%), ampicillin–sulbactam (44.4%), and co-trimoxazole (25.9%). No patients with pneumonia caused by <italic>E coli</italic> showed resistance to imipenem (<italic>P</italic> < 0.0001).</p> </sec> <sec> <title>Conclusion:</title> <p> <italic>E coli</italic> was resistant to many of the typically used antibiotics. No resistance was detected toward imipenem in patients with pneumonia caused by <italic>E coli</italic>.</p> </sec> </abstract>