The Relationship Between Cognitive Impairment and Global DNA Methylation Decrease Among Aluminum Potroom Workers. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Yang, Xiaojuan; Yuan, Yuzhou; Lu, Xiaoting; Yang, Jin; Wang, Linping; Song, Jing; Nie, Jisheng; Zhang, Qinli; Niu, Qiao
• Is Part Of: Journal of occupational and environmental medicine. Volume 57:Issue 7(2015)
• Publication Date: 2015-07
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000000474
• Languages: English
• ISSNs: 1076-2752

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective:</title> <p>To investigate the relationship between cognitive impairment and global DNA methylation in aluminum (Al) potroom workers.</p> </sec> <sec> <title>Methods:</title> <p>A total of 366 Al-exposed workers were investigated, and their cognitive functions were assessed with the Mini-Mental State Examination (MMSE). Aluminum in serum was quantified using graphite furnace atomic absorption spectrometry. Global DNA methylation was analyzed in whole blood using an enzyme-linked immunosorbent assay–like reaction.</p> </sec> <sec> <title>Results:</title> <p>Mini-Mental State Examination scores and global DNA methylation decreased with the increase of serum Al concentration. Forty-three mild cognitive impairment (MCI) people were diagnosed. Global DNA methylation of the MCI was lower than the non-MCI. Multiple logistic analysis showed that the Al-exposed workers had lower global DNA methylation and higher serum Al concentration and were at the higher risk of MCI.</p> </sec> <sec> <title>Conclusions:</title> <p>Long-term exposure to Al may cause MCI. Mild cognitive impairment was significantly associated with global DNA methylation in blood.</p> </sec> </abstract>