Does Lymphadenectomy Improve Survival in Uterine Leiomyosarcoma?. Issue 6 (July 2015)

• Record Type: Journal Article
• Authors: Tasci, Tolga; Karalok, Alper; Taskin, Salih; Ureyen, Isin; Kimyon, Gunsu; Tulek, Firat; Ozfuttu, Ahmet; Turan, Taner; Tulunay, Gokhan; Kose, M. Faruk; Ortac, Firat
• Is Part Of: International journal of gynecological cancer. Volume 25:Issue 6(2015:Jul.)
• Publication Date: 2015-07
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000452
• Languages: English
• ISSNs: 1048-891X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Introduction</title> <p>The role of lymphadenectomy in the management of uterine leiomyosarcoma (LMS) is controversial. We aimed to identify whether lymph node dissection (LND) has any survival benefit in uterine LMS.</p> </sec> <sec> <title>Methods</title> <p>Data of 95 patients with histologically proven uterine LMS from 2 tertiary centers (1993 through 2009) were retrospectively analyzed. Kaplan-Meier and Cox proportional hazards regression models were used for analyses.</p> </sec> <sec> <title>Results</title> <p>Mean age was 51.5 years. Thirty-six (37.9%) underwent LND. The median lymph node count was 54. Eight (22.2%) patients had lymphatic metastasis. Median follow-up was 26 months. Sixty-two (65%) patients had recurrence and 48 (50.5%) died. Median disease-free survival (DFS) was 19 months for both group of patients who had or did not have LND, and median overall survival (OS) was 29 and 26 months, respectively (<italic>P</italic> = 0.4). Five-year DFS was 35.9% vs 26.8% (<italic>P</italic> = 0.4), and 5-year OS was 45.4% vs 43.8% (<italic>P</italic> = 0.22) for the groups. Multivariate analyses did not reveal a single independent prognostic factor in respect to DFS or OS.</p> </sec> <sec> <title>Conclusion</title> <p>Higher rate of lymph node metastasis in patients with extrauterine disease indicated the importance of LND in LMS. However, the survival benefit of lymphadenectomy could not be shown.</p> </sec> </abstract>