External electrostatic field induced changes of rat erythrocyte membranes. Issue 4 (6th July 2015)

• Record Type: Journal Article
• Authors: Carlos F.R. Lemos Antunes, Professor; Sahakyan, G.V.; Artsruni, G.G.; Poghosyan, G.A.
• Is Part Of: Compel. Volume 34:Issue 4(2015)
• Page Start: 1054
• Page End: 1062
• Publication Date: 2015-07-06
• Subjects: Electrical engineering -- Data Processing -- Periodicals; Electrical engineering -- Mathematics -- Periodicals; Electrical engineering -- Periodicals; Electronics -- Data Processing -- Periodicals; Electronics -- Mathematics -- Periodicals; 621.3
• DOI: 10.1108/COMPEL-09-2014-0240
• Languages: English
• ISSNs: 0332-1649

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <sec> <title content-type="abstract-heading">Purpose</title> <p> – The purpose of this paper was to reveal the possible changes in membrane physical parameters, such as surface charge, <italic>ξ</italic>-potential and molecular interactions of membrane components due to the <italic>in vitro</italic> and <italic>in vivo</italic> influences of ESF. </p> </sec> <sec> <title content-type="abstract-heading">Design/methodology/approach</title> <p> – The <italic>in vitro</italic> and <italic>in vivo</italic> (one hour) influences of 200 kV/m external electrostatic field (ESF) on the erythrocyte membranes of white outbred rats were investigated by spectrofluorometric, spectral and electrophoretic methods. </p> </sec> <sec> <title content-type="abstract-heading">Findings</title> <p> – It was shown that the <italic>in vivo</italic> influence of ESF leads to the intermolecular reconstructions and decrease of the positive charged groups in membrane surface layer. At the same time, the increases of the negative charged groups of membrane proteins after the field influence, is revealed. The charge redistribution in membranes due to the <italic>in vitro</italic> influence of ESF is observed. </p> </sec> <sec> <title content-type="abstract-heading">Originality/value</title> <p> – The analysis of literature data and generalization of data obtained allow us concluding that in parallel with the polarization of lipid component of bilayer the changes in the structural state of membrane proteins take place due to the ESF influence on the erythrocyte membranes. These changes can be the reason and/or the result of the ESF induced redistribution of membrane charge.</p> </sec> </abstract>