Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils. Issue 2 (October 2015)

• Record Type: Journal Article
• Authors: Conejeros, Iván; Gibson, Amanda J.; Werling, Dirk; Muñoz-Caro, Tamara; Hermosilla, Carlos; Taubert, Anja; Burgos, Rafael A.
• Is Part Of: Developmental and comparative immunology. Volume 52:Issue 2(2015)
• Page Start: 215
• Page End: 225
• Publication Date: 2015-10
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2015.05.012
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">TLR ligands induce morphology changes and the phagocytosis activity in bovine PMN.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Bovine PMN express TLR2 and TLR4 at the membrane surface.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Pam₃CSK₄ induces calcium influx, ROS production and MMP-9 secretion.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">The ROS production induced by Pam₃CSK₄ was blocked by the SOCE inhibitor 2-APB.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Incubation with TLR ligands does not affect the apoptosis of bovine PMN.</p> </list-item> </list> </p> </sec> </abstract>