P11. Connectivity-based predictions of hand motor outcome at the sub-acute stage after stroke. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Lindow, J.; Domin, M.; Grothe, M.; Byblow, W.; Lotze, M.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 8(2015:Aug.)
• Page Start: e93
• Publication Date: 2015-08
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.04.132
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="sp005">Predicting motor recovery after stroke is a recognized aim in stroke rehabilitation. Here, we combine two different neuroimaging methods to test their prognostic power at the sub-acute stage after stroke. We measured resting state fMRI (rs-fMRI) and diffusion weighted imaging (DWI) in 19 stroke patients within the first days (5–9 days) after stroke and investigated short term (3 months) and long term (6 months) motor outcome.</p> <p id="sp010">Resting-state functional connectivity (rs-FC) showed no relevant predictive value for motor outcome. We found trends for negative associations between the rs-FC of primary motor cortex (M1) of the lesioned hemisphere and dorsal premotor cortices (dPMC) of the contralesional side with grip force of the affected upper limb at 3 months. In addition, a poorer short-term outcome for pinch grip performance was associated with rs-FC of M1 and the supplementary motor area (SMA) in the lesioned hemisphere. In contrast DWI showed a predictive value for both short-term and long-term motor outcome. Integrity along the M1-pons tract showed good predictive value for a positive outcome at 6 months. Overall, structural connectivity measures derived from probabilistic DWI may offer better prognostic information than rs-fMRI at the early phase after stroke.</p> </sec> </abstract>