P93. Ictal SPECT in patients with REM sleep behavior disorder. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Mayer, G.; Stefan, H.; Kuwert, T.; Bitterlich, M.
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 8(2015:Aug.)
• Page Start: e148
• Publication Date: 2015-08
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.04.243
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="st005">Introduction</title> <p id="sp005">Patients with idiopathic REM sleep behavior disorder (iRBD) have the same phenotype as those with Parkinson and RBD (PD + RBD) and narcolepsy and RBD (nRBD). Little is known if different types of RBD share the same pathways during their nocturnal activities. The aim of the study was to compare ictal SPECT of different types of RBD.</p> </sec> <sec> <title id="st010">Methods</title> <p id="sp010">Recording was performed as 22 channel video-EEG polysomnography using an IT- Med system l. Ictal and interictal subtraction SPECT was performed after using a semiautomatic SPECT injection device permitting immediate intravenous application of the radioligand ECD with a latency <10 s between onset of clinical event and injection. Patients were injected with 898 MBq Tc-99 m ECD (NeuroLite, Bristol-Myers Squibb). Injection was done when REM sleep lasted > or 10 epochs and complex behavior in REM sleep > 10 epochs. Ictal and interictal reconstructed datasets were subtracted pixelwise from each other, the difference images were coregistered to MRI images.</p> </sec> <sec> <title id="st015">Patients</title> <p id="sp015">2 iRBD, 2 with nRBD. 1 iRBD patient had converted to Parkinson's disease (Hoehn & Yahr 4). Patients fulfilled RBD criteria according to the International Classification of Sleep Disorders 2 (2005). All patients gave their written consent. The study was approved by the Ethical Committee of the Chamber of Physicians of the state of Hessen/Germany.</p> </sec> <sec> <title id="st020">Results</title> <p id="sp020">All patients independent of their RBD type displayed a similar pattern of activation in the ictal SPECT. The activation included the premotor areas bilaterally, the interhemispheric cleft, the periaqueductal area, the dorsal and ventral pons and the anterior part of the cerebellum.</p> </sec> <sec> <title id="st025">Conclusion</title> <p id="sp025">The ictal pathway of RBD is the same in iRBD, PD + RBD and nRBD.</p> </sec> </abstract>