A longitudinal study of ABC transporter expression in canine multicentric lymphoma. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Zandvliet, M.; Teske, E.; Schrickx, J.A.; Mol, J.A.
• Is Part Of: Veterinary journal. Volume 205:Issue 2(2015)
• Page Start: 263
• Page End: 271
• Publication Date: 2015-08
• Subjects: Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2014.11.002
• Languages: English
• ISSNs: 1090-0233

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Drug resistance is a major cause of treatment failure in canine lymphoma.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">ABC transporter overexpression is an important drug resistance mechanism in vitro.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>ABCB1, ABCB5, ABCC5</italic> and <italic>ABCG2</italic> overexpression is associated with in vivo drug resistance.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">ABC transporter expression is not prognostic, suggesting that other resistance mechanisms are present in canine lymphoma.</p> </list-item> </list> </p> </sec> </abstract>