Controlled‐release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers. Issue 38 (17th June 2015)

• Record Type: Journal Article
• Authors: Jia, Chengying; Song, Junlong; Jin, Yongcan; Rojas, Orlando J.
• Is Part Of: Journal of applied polymer science. Volume 132:Issue 38(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-06-17
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.42562
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>We report a facile method to synthesize hollow silica microtubes (SMTs) from electrospun cellulose acetate fiber precursors. Specific surface areas of up to 765 m²/g (Brunauer–Emmett–Teller) were measured for the SMTs, which had a typical wall thickness of ∼100 nm and submicron inner diameters. An average pore size of 4.6 nm and pore volume of 0.41 cm³/g were derived from Barrett–Joyner–Halenda fitting, whereas Horvath–Kawazoe pore size distribution analysis revealed microporous median pore size and maximum pore volume of 0.7 nm and 0.18 cm³/g, respectively. The as‐prepared SMTs featuring micro‐ and mesoporous structures in the walls where amino‐functionalized to facilitate a very high drug loading (15% by weight). Drug release profile revealed sustained release rates (79% of acetylsalicylic acid was released after 6 h). It is concluded that the high drug loading and sustained release resulted from the advantageous integration of SMTs' hollow structure and wall mesoporosity. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2015</bold>, <italic>132</italic>, 42562.</p> </abstract>