Departure gate of acidic Ca2+ confirmed. (28th May 2015)

• Record Type: Journal Article
• Authors: Jentsch, Thomas J; Hoegg‐Beiler, Maja B; Vogt, Janis
• Is Part Of: EMBO journal. Volume 34:Number 13(2015)
• Page Start: 1737
• Page End: 1739
• Publication Date: 2015-05-28
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201591884
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201591884-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">More potent, but less known than IP₃ that liberates Ca²⁺ from the ER, NAADP releases Ca²⁺ from acidic stores. The notion that TPC channels mediate this Ca²⁺ release was questioned recently by studies suggesting that TPCs are rather PI(3, 5)P₂‐activated Na⁺ channels. Ruas <italic>et al</italic> (2015) now partially reconcile these views by showing that TPCs significantly conduct both cations and confirm their activation by both NAADP and PI(3, 5)P₂. They attribute the failure of others to observe TPC‐dependent NAADP‐induced Ca²⁺ release <italic>in vivo</italic> to inadequate mouse models that retain partial TPC function.</p> </abstract>