Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions. (15th May 2015)

• Record Type: Journal Article
• Authors: Guasch, Judith; Conings, Bert; Neubauer, Stefanie; Rechenmacher, Florian; Ende, Karen; Rolli, Claudio G.; Kappel, Christian; Schaufler, Viktoria; Micoulet, Alexandre; Kessler, Horst; Boyen, Hans‐Gerd; Cavalcanti‐Adam, Elisabetta Ada; Spatz, Joachim P.
• Is Part Of: Advanced materials. Volume 27:Number 25(2015)
• Page Start: 3737
• Page End: 3747
• Publication Date: 2015-05-15
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201500900
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201500900-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Orthogonally functionalized binary micropatterned substrates</bold> are produced using a novel protocol. The use of adequate peptido‐mimetics enables an unprecedented segregation of purified αvβ3 and α5β1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors. Moreover, this tendency can be altered by varying the geometry and composition of the micropatterns. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj1d0h9g87" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>