Type 2 diabetes as a protein misfolding disease. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Mukherjee, Abhisek; Morales-Scheihing, Diego; Butler, Peter C.; Soto, Claudio
• Is Part Of: Trends in molecular medicine. Volume 21:Issue 7(2015)
• Page Start: 439
• Page End: 449
• Publication Date: 2015-07
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2015.04.005
• Languages: English
• ISSNs: 1471-4914

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Accumulation of islet amyloid is present in &gt;90% of patients with T2D.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">There is evidence for a role of misfolded IAPP aggregates in β-cell dysfunction.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">IAPP aggregates are similar to protein aggregates implicated in neurological diseases.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">T2D should be considered a PMD.</p> </list-item> </list> </p> </sec> </abstract>