Cardiac-specific overexpression of metallothionein attenuates myocardial remodeling and contractile dysfunction in l-NAME-induced experimental hypertension: Role of autophagy regulation. Issue 2 (2nd September 2015)

• Record Type: Journal Article
• Authors: Yang, Lifang; Gao, Jian-Yuan; Ma, Jipeng; Xu, Xihui; Wang, Qiurong; Xiong, Lize; Yang, Jian; Ren, Jun
• Is Part Of: Toxicology letters. Volume 237:Issue 2(2015)
• Page Start: 121
• Page End: 132
• Publication Date: 2015-09-02
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.06.005
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0045"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We examined the impact of <sc>l</sc>-NAME-induced hypertension on cardiac responses.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010"> <sc>l</sc>-NAME challenge altered cardiac morphology, function and autophagy.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Metallothionein alleviated <sc>l</sc>-NAME-induced anomalies in cardiac structure and function.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The beneficial effect of metallothionein may be mediated through restored autophagy.</p> </list-item> </list> </p> </sec> </abstract>