Antibody treatment against pulmonary exposure to abrin confers significantly higher levels of protection than treatment against ricin intoxication. Issue 2 (2nd September 2015)

• Record Type: Journal Article
• Authors: Sabo, Tamar; Gal, Yoav; Elhanany, Eitan; Sapoznikov, Anita; Falach, Reut; Mazor, Ohad; Kronman, Chanoch
• Is Part Of: Toxicology letters. Volume 237:Issue 2(2015)
• Page Start: 72
• Page End: 78
• Publication Date: 2015-09-02
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.06.003
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0030"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Pulmonary exposure of mice to abrin leads to neutrophilic inflammation of the lungs.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Lung pathology following abrin intoxication resembles that of ricin.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Efficient Ab-based protection is achieved following abrin but not ricin exposure.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Ab treatment against abrin, but not against ricin, reduces pulmonary IL-6 levels.</p> </list-item> </list> </p> </sec> </abstract>