Protective effect of 1, 25-dihydroxyvitamin D3 on ethanol-induced intestinal barrier injury both in vitro and in vivo. Issue 2 (2nd September 2015)

• Record Type: Journal Article
• Authors: Chen, Shan-wen; Ma, Yuan-yuan; Zhu, Jing; Zuo, Shuai; Zhang, Jun-ling; Chen, Zi-yi; Chen, Guo-wei; Wang, Xin; Pan, Yi-sheng; Liu, Yu-cun; Wang, Peng-yuan
• Is Part Of: Toxicology letters. Volume 237:Issue 2(2015)
• Page Start: 79
• Page End: 88
• Publication Date: 2015-09-02
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.06.006
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0045"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">1, 25(OH)₂D₃ is able to attenuate ethanol-induced intestinal epithelial barrier injury in Caco-2 monolayers.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Vitamin D sufficient mice are more resistant to the injury of intestinal epithelial barrier injury induced by ethanol.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The suppression of ethanol-induced generation of ROS and increased phosphorylation level of MLC might be one of the mechanisms underlying the protective effect of 1, 25(OH)₂D₃.</p> </list-item> </list> </p> </sec> </abstract>