The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Zhao, Jiuda; Du, Feng; Luo, Yang; Shen, Guoshuang; Zheng, Fangchao; Xu, Binghe
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 7(2015)
• Page Start: 623
• Page End: 633
• Publication Date: 2015-07
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.05.004
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">We first summarize the contribution of HIF-2α in chemo/radioresistance in solid tumors.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">Studies assessing the roles of HIF-2α on drug resistance are scarce compared to those on HIF-1 in solid tumors.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Some new mechanisms contribute to HIF-2 resistance to chemo/radioresistance.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">We further discuss HIF-2 inhibitors and the different mechanisms of HIF-2- and HIF-1-mediated chemo/radioresistance.</p> </list-item> </list> </p> </sec> </abstract>