Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Economopoulou, Panagiota; Mountzios, Giannis; Pavlidis, Nicholas; Pentheroudakis, George
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 7(2015)
• Page Start: 598
• Page End: 604
• Publication Date: 2015-07
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.05.010
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="st005">Highlights</title> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Gene expression profiling (GEP) assays assign Cancer of Unknown Primary (CUP) cases to the most likely tissue of origin.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">A survival benefit in CUP patients managed with tissue-specific antineoplastic therapy after use of a GEP assay is unproven.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">There is no consensus on the most cost-effective way to incorporate the GEP CUP assays in the current diagnostic algorithm.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">The search for a CUP molecular signature responsible for its atypical behavior has not been done systematically.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Regarding targeting, the assumption that the same gene mutation matters in the same way across tumor types is unproven.</p> </list-item> </list> </p> </sec> </abstract>