Toll like receptors and pancreatic diseases: From a pathogenetic mechanism to a therapeutic target. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Santoni, Matteo; Andrikou, Kalliopi; Sotte, Valeria; Bittoni, Alessandro; Lanese, Andrea; Pellei, Chiara; Piva, Francesco; Conti, Alessandro; Nabissi, Massimo; Santoni, Giorgio; Cascinu, Stefano
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 7(2015)
• Page Start: 569
• Page End: 576
• Publication Date: 2015-07
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.04.004
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Toll-like receptors mediate interactions between environmental stimuli and innate immunity.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">TLRs play a crucial role in the development of acute pancreatitis and SIRS.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">TLR2, TLR4, TLR7 and TLR9 are involved in type 1 and 2 diabetes mellitus.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">TLRs promote pancreatic carcinogenesis and epithelial–mesenchymal transition.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">TLRs represent a promising target for pancreatitis, diabetes and pancreatic cancer.</p> </list-item> </list> </p> </sec> </abstract>