Synergism between genome sequencing, tandem mass spectrometry and bio-inspired synthesis reveals insights into nocardioazine B biogenesis1. Issue 26 (14th July 2015)

• Record Type: Journal Article
• Authors: Alqahtani, Norah; Porwal, Suheel K.; James, Elle D.; Bis, Dana M.; Karty, Jonathan A.; Lane, Amy L.; Viswanathan, Rajesh
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 26(2015)
• Page Start: 7177
• Page End: 7192
• Publication Date: 2015-07-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00537j
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj1c6cfs18" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A <italic>noz</italic> gene cluster encoded by <italic>Nocardiopsis</italic> sp. CMB M0232 is presented, revealing the actinomycetes' unique indole methylating and prenylating patterns, leading to anticancer nocardioazine alkaloids.</p> </abstract>