Iodine(III)‐Mediated para‐Selective Direct Imidation of Anilides. Issue 28 (10th June 2015) - Pialat, Amélie
Abstract The direct, nucleophilic imidation of acetanilide derivatives has been performed under mild, iodine(III)‐mediated or ‐catalyzed conditions, employing lithium triflimide as the nitrogen source. The reaction exhibits exclusive regioselectivity for the para position and shows a good tolerance for varied functional groups at both the ortho or meta positions. Preliminary mechanistic data suggest that the LiNTf2 reagent plays a key role in the reactivity.