Inside Cover: Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro‐1 as Potent Inhibitors of Shiga Toxin (ChemMedChem 7/2015). Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Abdelkafi, Hajer; Michau, Aurélien; Clerget, Alexandra; Buisson, David‐Alexandre; Johannes, Ludger; Gillet, Daniel; Barbier, Julien; Cintrat, Jean‐Christophe
• Is Part Of: ChemMedChem. Volume 10:Issue 7(2015:Jul.)
• Page Start: 1118
• Page End: 1118
• Publication Date: 2015-07
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201590020
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> Retro‐1, a benzodiazepine that blocks the retrograde transport in host cells of Shiga toxins, the virulence factors produced by pathogenic strains of <italic>E. coli</italic> responsible for food poisoning and hemolytic uremic syndrome. After synthesis and separation, the <italic>S</italic>‐enantiomer was found to be more effective at protecting human cells from Shiga toxins. For further details, see the Communication by Daniel Gillet, Jean‐Christophe Cintrat et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 1153 ff.</ext-link><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj19wwd35w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>