HDAC8: a multifaceted target for therapeutic interventions. (July 2015)

• Record Type: Journal Article
• Authors: Chakrabarti, Alokta; Oehme, Ina; Witt, Olaf; Oliveira, Guilherme; Sippl, Wolfgang; Romier, Christophe; Pierce, Raymond J.; Jung, Manfred
• Is Part Of: Trends in pharmacological sciences. Volume 36:Number 7(2015)
• Page Start: 481
• Page End: 492
• Publication Date: 2015-07
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2015.04.013
• Languages: English
• ISSNs: 0165-6147

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">HDAC8, a unique class I HDAC, recognizes both histone and nonhistone substrates.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">HDAC8 is implicated in cancer, schistosomiasis, and Cornelia de Lange syndrome.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Structural specificities of HDAC8 allow the design of selective inhibitors.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Drug development is underway to combat diseases linked with HDAC8.</p> </list-item> </list> </p> </sec> </abstract>