MicroRNA-21 Expression is Elevated in Esophageal Adenocarcinoma After Neoadjuvant Chemotherapy. (3rd July 2015)

• Record Type: Journal Article
• Authors: Ilhan-Mutlu, Aysegül; Tezcan, Gülcin; Schoppmann, Sebastian F.; Preusser, Matthias; Spyridoula, Kommata; Karanikas, Georgios; Birner, Peter
• Is Part Of: Cancer investigation. Volume 33:Number 6(2015)
• Page Start: 246
• Page End: 250
• Publication Date: 2015-07-03
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2015.1024319
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title>ABSTRACT</title> <p>We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET–CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (<italic>p</italic> = .027). No association of microRNA-21 or microRNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of microRNA-21 might represent an escape mechanism of tumor cells.</p> </abstract>