Metabolic syndrome is common and persistent in youth‐onset type 2 diabetes: Results from the TODAY clinical trial. (5th June 2015)

• Record Type: Journal Article
• Authors: Weinstock, Ruth S.; Drews, Kimberly L.; Caprio, Sonia; Leibel, Natasha I.; McKay, Siripoom Vudhipoom; Zeitler, Philip S.; for the TODAY Study Group
• Is Part Of: Obesity. Volume 23:Number 7(2015:Jul.)
• Page Start: 1357
• Page End: 1361
• Publication Date: 2015-06-05
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21120
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby21120-sec-0001" sec-type="section"> <title>Objective</title> <p>To examine the prevalence of metabolic syndrome (MetS) in youth‐onset type 2 diabetes in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study.</p> </sec> <sec id="oby21120-sec-0002" sec-type="section"> <title>Methods</title> <p>Prevalence of MetS (ATP III definition) was compared at baseline (<italic>n</italic> = 679) and at 6 (<italic>n</italic> = 625) and 24 months (<italic>n</italic> = 545) using chi‐square tests. Laboratory data were examined between MetS classifications at each time point using ANOVA.</p> </sec> <sec id="oby21120-sec-0003" sec-type="section"> <title>Results</title> <p>Baseline prevalence of MetS was 75.8% and did not differ by treatment group or change over time. MetS was more common in females (83.1%) than males (62.3%; <italic>P</italic> < 0.0001) at baseline; this difference persisted over 24 months. Prevalence of MetS was similar between ethnic groups at baseline but greater in Hispanics (82.7%) vs. non‐Hispanic Whites (67.5%; <italic>P</italic> = 0.0017) and non‐Hispanic Blacks (72.7%; <italic>P</italic> = 0.0164) at 24 months. Although MetS was common in participants with hemoglobin A1c < 7.0% (74.4% at baseline; no significant change over 24 months), it was more common in those who did not maintain glycemic control at 6 months (80.3%; <italic>P</italic> = 0.0081). Elevated C‐reactive protein, ALT, IL‐6, and PAI‐1 levels were more frequent with MetS.</p> </sec> <sec id="oby21120-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Persistent high prevalence of MetS in youth‐onset diabetes, even with excellent glycemic control, is of concern given the associated increased cardiovascular risk.</p> </sec> </abstract>