Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later. (July 2015)

• Record Type: Journal Article
• Authors: Unick, Jessica L.; Neiberg, Rebecca H.; Hogan, Patricia E.; Cheskin, Lawrence J.; Dutton, Gareth R.; Jeffery, Robert; Nelson, Julie A.; Pi‐Sunyer, Xavier; West, Delia Smith; Wing, Rena R.; the Look AHEAD Research Group
• Is Part Of: Obesity. Volume 23:Number 7(2015:Jul.)
• Page Start: 1353
• Page End: 1356
• Publication Date: 2015-07
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21112
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby21112-sec-0001" sec-type="section"> <title>Objective</title> <p>Examine the relationship between 1‐ and 2‐month weight loss (WL) and 8‐year WL among participants enrolled in a lifestyle intervention.</p> </sec> <sec id="oby21112-sec-0002" sec-type="section"> <title>Methods</title> <p>2, 290 Look AHEAD participants (BMI: 35.65 ± 5.93 kg/m<sup>2</sup>) with type 2 diabetes received an intensive behavioral WL intervention.</p> </sec> <sec id="oby21112-sec-0003" sec-type="section"> <title>Results</title> <p>1‐ and 2‐month WL were associated with yearly WL through Year 8 (<italic>P</italic>'s < 0.0001). At Month 1, participants losing 2‐4% and >4% had 1.62 (95% CI: 1.32, 1.98) and 2.79 (95% CI: 2.21, 3.52) times higher odds of achieving ≥5% WL at Year 4 and 1.28 (95% CI: 1.05, 1.58) and 1.77 (95% CI: 1.40, 2.24) times higher odds of achieving ≥5% WL at Year 8, compared to those losing <2% initially. At Month 2, 3‐6% WL resulted in greater odds of achieving ≥5% WL at Year 4 (OR = 1.85; CI: 1.48, 2.32), and >6% WL resulted in the greatest odds of achieving ≥5% WL at Year 4 (OR = 3.85; CI: 3.05, 4.88) and Year 8 (OR = 2.28; CI: 1.81, 2.89), compared to those losing <3%. Differences in adherence between WL categories were observed as early as Month 2.</p> </sec> <sec id="oby21112-sec-0004" sec-type="section"> <title>Conclusions</title> <p>1‐ and 2‐month WL was associated with 8‐year WL. Future studies should examine whether alternative treatment strategies can be employed to improve treatment outcomes among those with low initial WL.</p> </sec> </abstract>