PEGylated nanostructured lipid carriers (PEG–NLC) as a novel drug delivery system for biochanin A. (July 2015)

• Record Type: Journal Article
• Authors: Wang, Lei; Luo, Qing; Lin, Tongyuan; Li, Rui; Zhu, Tingting; Zhou, Kai; Ji, Zhaojie; Song, Jiawei; Jia, Buyun; Zhang, Caiyun; Chen, Weidong; Zhu, Guangyu
• Is Part Of: Drug development and industrial pharmacy. Volume 41:Number 7(2015:Jul.)
• Page Start: 1204
• Page End: 1212
• Publication Date: 2015-07
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.3109/03639045.2014.938082
• Languages: English
• ISSNs: 0363-9045

Abstract

<abstract> <title>Abstract</title> <p>With the aim to develop a lipid nanoparticle for biochanin A (BCA) by emulsion-evaporation and low temperature-solidification technique. The results revealed that BCA–PEG–NLC not only have small mean particle (148.5 ± 2.88 nm) with narrow polydispersity index (PI) (0.153 ± 0.01), encapsulation capacity (99.62 ± 0.06%), payload (9.06 ± 0.01%), zeta potential (−19.83 ± 1.19 mV), but also slower release rate compared with BCA suspension over 48 h by the dialysis method (<italic>n</italic>=3). The crystallinity of lipid matrix within BCA–PEG–NLC was evaluated by differential scanning calorimetry (DSC) which verified the BCA successfully into the nanoparticles. Particularly, in pharmacokinetic, the BCA–PEG–NLC of <italic>C</italic>_max values and AUC (area under curve) was higher than BCA suspension (approximately 15.8 and 2.9 times, respectively), meanwhile, the mean residence time (MRT) was significantly longer. Furthermore, <italic>in vitro</italic> cytotoxicity BCA–PEG–NLC showed higher cytotoxicity against MCF-7 cell line compared with BCA suspension. This study suggested that PEG–NLC is a novel anti-cancer nanoparticle, which could provide attractive treatment for a wide variety of tumors and improved the oral bioavailability of poorly water-soluble drug.</p> </abstract>